Clofi is a synthetic non-steroidal medication that closely resembles the structure of estrogen. It is commonly utilized as an ovulatory stimulant. Due to its similarity to estrogen, Clofi can attach to estrogen receptors in the hypothalamus, preventing the hypothalamus from detecting "real" estrogen. This leads the hypothalamus to stimulate the pituitary gland, which then releases more gonadotropins such as FSH and LH. The increased levels of FSH and LH, in turn, prompt the ovaries or testes to produce additional estrogen or testosterone.
This characteristic of Clofi has been effectively employed to treat women suffering from ovarian failure and to induce ovulation. Nonetheless, prolonged use of this medication may pose safety concerns, particularly due to the heightened risk of ovarian cancer.
Clofi is a large molecule that is soluble in various organic solvents, including alcohol. The sodium salt citrate variant is also water-soluble. The substance itself is odorless. Clomiphene is available in 50 mg tablet form. Before commencing treatment, patients must be thoroughly evaluated for all gynecological and endocrine issues.
Ovulation generally occurs within 5-10 days after initiating Clomiphene. Intercourse should be timed to align with the anticipated ovulation period. Treatment typically starts with a dosage of 50 mg/day for 5 days, which may be increased for women who do not ovulate.
Clofi is administered once daily. Bodybuilding experts recommend its use either alone or in combination with low-potency anabolic steroids. Many bodybuilders use anabolic steroids for a few months before transitioning to Clomid. Clofi aids in boosting testosterone levels and helps prevent breast enlargement. The optimal timing for starting Clomid is not well-defined, but it is advised to begin Clofi within 7-10 days after stopping steroid use.
When taken at the advised doses for a short duration, Clofi is typically regarded as safe. Most side effects experienced are temporary and resolve once treatment is discontinued.
Common adverse reactions may include flushing, abdominal discomfort, nausea, vomiting, breast tenderness, headaches, abnormal vaginal bleeding, general fatigue, and hair loss.